Diabetes Complications – Molecular, Pathophysiological, and Clinical Perspectives

Diabetes Complications – Molecular, Pathophysiological, and Clinical Perspectives

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Description

Diabetes mellitus (DM) is a common ailment known to humans for thousands of years. In spite of this, the prevalence of DM continues to increase. The most current data show that the world-wide prevalence of DM in the adult population stands at 537 million. Despite the efforts made by researchers, governments, healthcare providers and others, it is estimated that the number of people with DM will increase to 783 million by 2045. DM is caused by the inability of insulin to transport glucose from the blood to target tissues such as skeletal muscle and liver, leading to hyperglycemia. Chronic hyperglycemia in turn leads to oxidative stress, glycation of proteins, and impaired metabolism of lipids and carbohydrates. All of these factors further induce cascades of signaling pathways, resulting in acute and chronic complications of DM. The signs and symptoms of DM include but are not limited to tiredness, polydipsia, and polyuria. Other signs of metabolic disorders such as hypertension, atherosclerosis and dyslipidemia may also be seen in patients with DM. The outcome of untreated DM is chronic complications in the form of retinopathy, neuropathy, nephropathy and severe damage to blood vessels and other organs of the body.

ISBN

ISBN: 979-8-90134-141-4

Publication Date

4-13-2026

Publisher

Nova Medicine and Health

Disciplines

Medicine and Health Sciences

Diabetes Complications – Molecular, Pathophysiological, and Clinical Perspectives

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