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Diabetes Complications – Molecular, Pathophysiological, and Clinical Perspectives
Ernest A. Adeghate and Jaipaul Singh
Diabetes mellitus (DM) is a common ailment known to humans for thousands of years. In spite of this, the prevalence of DM continues to increase. The most current data show that the world-wide prevalence of DM in the adult population stands at 537 million. Despite the efforts made by researchers, governments, healthcare providers and others, it is estimated that the number of people with DM will increase to 783 million by 2045. DM is caused by the inability of insulin to transport glucose from the blood to target tissues such as skeletal muscle and liver, leading to hyperglycemia. Chronic hyperglycemia in turn leads to oxidative stress, glycation of proteins, and impaired metabolism of lipids and carbohydrates. All of these factors further induce cascades of signaling pathways, resulting in acute and chronic complications of DM. The signs and symptoms of DM include but are not limited to tiredness, polydipsia, and polyuria. Other signs of metabolic disorders such as hypertension, atherosclerosis and dyslipidemia may also be seen in patients with DM. The outcome of untreated DM is chronic complications in the form of retinopathy, neuropathy, nephropathy and severe damage to blood vessels and other organs of the body.
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Illustrations, comics and graphic novels from the UAE
Sarah Nesti Willard
This chapter overviews emergent communities of illustrations, comics, and graphic narratives from the United Arab Emirates. The data collected is from ethnographic online and on-site observations and direct interactions with Emirati artists and publishers. It briefly discusses how comics and graphic narratives have evolved in the last 20 years, and it elucidates how these art forms avail social media to gain prominence and recognition. It then introduces a group of 21 Emirati artists, all different in style and concept, who have been chosen to represent a new illustrative trend: Khaleeji comics and illustrations. Their first group exhibition is with the University of Turin, in collaboration with the Lab Anzaar, organised by the Department of Literature and Modern Languages. The works of art discussed in this chapter are those exhibited in Palazzo Aldo Moro, Turin, on the 15th of May 2024. Emirati artists are introduced, and their work is briefly described. The chapter also emphasizes the importance of defining a modern pop-cultural identity within the region.
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