Date of Defense
14-11-2023 2:00 PM
Location
F3-226
Document Type
Thesis Defense
Degree Name
Master of Science in Molecular Biology and Biotechnology
College
COS
Department
Biology
First Advisor
Dr. Khalid Mohammad
Keywords
Atopic Dermatitis, UAE population, HLA genetic variations, HLA-A, HLA-DRB1, eczema
Abstract
In the face of the increasing global prevalence of Atopic Dermatitis (AD), a chronic inflammatory skin condition, this thesis seeks to elucidate the genetic underpinnings of AD within the UAE population. Previous literature has underscored the ethnic-specific involvement of HLA genetic variations, especially within HLA-A and HLA-DRB1 genes, in the pathogenesis of various skin diseases, including AD. Leveraging this knowledge, our research specifically aimed to investigate the association between these HLA variants and AD in the UAE. Utilizing a comparative approach, the frequencies of HLA-A and HLA-DRB1 variants were assessed in AD patients vis-à-vis a control group. Our data, based on frequency data and corroborated by z-test and chi-square statistical analyses, indicated a non-specific association of any of the HLA-A or HLA-DRB1 variants within AD susceptibility or protection.
Included in
ASSOCIATION OF HUMAN LEUKOCYTE ANTIGEN (HLA) ALLELES WITH ATOPIC DERMATITIS IN THE UAE POPULATION
F3-226
In the face of the increasing global prevalence of Atopic Dermatitis (AD), a chronic inflammatory skin condition, this thesis seeks to elucidate the genetic underpinnings of AD within the UAE population. Previous literature has underscored the ethnic-specific involvement of HLA genetic variations, especially within HLA-A and HLA-DRB1 genes, in the pathogenesis of various skin diseases, including AD. Leveraging this knowledge, our research specifically aimed to investigate the association between these HLA variants and AD in the UAE. Utilizing a comparative approach, the frequencies of HLA-A and HLA-DRB1 variants were assessed in AD patients vis-à-vis a control group. Our data, based on frequency data and corroborated by z-test and chi-square statistical analyses, indicated a non-specific association of any of the HLA-A or HLA-DRB1 variants within AD susceptibility or protection.