Date of Award
Master of Science (MS)
Dr. Abdul Jaleel Cheruth
Dr. Shyam S. Kurup
Natural products provide many bioactive lead molecules for the discovery of new medicines. Naturally, derived phytochemicals have exhibited tremendous biological activities including anticancer activity. More than 60% of antitumor medicines are closely associated with natural products. In the present study, hexane, chloroform, acetone and, methanol extracts from roots of Moringa peregrina were screened for phytochemical analysis and anticancer activity. Phytochemical analysis was performed by Gas Chromatography and Mass spectrometry (GC-MS). The anticancer potential of the extracts was done on the human breast cancer cell line (MCF-7) and cell viability was measured using WST-1 Cell Proliferation Assay Kit. The cell line was treated with different concentrations (10, 20, 40, 80, 160, and 320 μg/ml) of plant extracts and the results were compared with the standard drug Doxorubicin. The results of GC-MS analysis of different extracts revealed the presence of various compounds. The anticancer studies revealed that the chloroform extract of M. peregrina has good activity against the human breast cancer cell line with the IC50 value of 127.38 μg/ml. The IC50 values of hexane, acetone, and methanol extracts were 315.0, 284.8, and 353.10 μg/ml respectively. Whereas the IC50 value of the standard drug, Doxorubicin was 25.88 μg/ml. Based on these results, further study is warranted for the isolation of anticancer molecules from chloroform extract of M. peregrina root tubers.
Saeed Al Kaabi, Salama Khamis Sultan, "EVALUATION OF PHYTOCHEMICAL COMPOSITION AND ANTI-CANCER POTENTIAL IN ROOT EXTRACTS OF MORINGA PEREGRINA (FORSSK.) FIORI" (2019). Theses. 765.