Date of Award
Master of Science (MS)
Na’il Saleh Ibrahim
Mohamed Alazab Alnaqbi
Herein, we describe the synthesis of a bioactive, inexpensive, and easy-tohandle supramolecular carbohydrate polymer by grafting of cucurbit  uril macrocycle (CB7)-encapsulated dequalinium chloride hydrate (DCH) onto alginic acid carbohydrates (ALG) via amide linkage formation and show that light energy transfer based on energy migration can be controlled by altering polymer temperature without changing polymer composition. DCH (donor) and 2-anilinonaphthalene-6- sulfonic acid (acceptor) were used to generate Förster resonance energy transfer (FRET) signals. Stationary and time-resolved photoluminescence spectra of the modified carbohydrate platform revealed that FRET resulted in a color change from violet (~387 nm) to blue (~429 nm), which could be repeatedly switched on and off in response to temperature stimuli at 298–368 K. NMR measurements suggested that the responsiveness of DCH/CB7ALG to thermal stimuli was due to the threading of CB7 onto the DCH backbone in solution and upon grafting onto ALG polymers.
Alam Jan, Amir Sohail Noor, "Alginate/Cucurbit  Uril/Dequalinium–Basedb Supramolecular Carbohydrates: Modulation of Fret Signal by Temperature Control" (2019). Chemistry Theses. 7.