Date of Award

5-2012

Document Type

Thesis

Degree Name

Master of Science in Material Science Engineering (MSMatSE)

Department

Materials Science

First Advisor

Dr. Ali Al-Marzouqi

Second Advisor

Dr. Mahmood Mohsin

Abstract

Osteoarthritis is a disease that attacks human bones especially in older people and usually nonsteroidal anti-inflammatory drugs (NSAIDS) are being prescribed for patients with Osteoarthritis. These kinds of drugs usually have low aqueous solubility and in order to have their therapeutic effects, their solubility should be enhanced. The purpose of this study was to find solution for this problem and one way to do that is to reduce the particle size by forming micro particles. In this project, one of these types of drugs ibuprofen (isobutyl-propanoicphenolic Acid) was encapsulated into a polymer (PVP polyvinylpyrrolidone) using supercritical fluid technology (Supercritical CO2) to form drug-polymer micro particles. Another aim was to measure the solubility, dissolution rate and surface characteristics of the prepared drug-polymer micro particles by characterizing them using various characterization techniques such as fourier transform infrared spectroscopy (FTIR) , ultraviolet spectroscopy (UV), transmission electron microscopy (TEM), scanning electron microscope (SEM), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Various drug-polymer formulations were prepared depending on various administrative dosages. Different conditions (i.e. different temperatures, pressures, flow rates and different drug solution: CO2 volume ratio) were tested in preparing drug-polymer micro particles. Results from TEM images and FT -IR graphs show that micro particles were successfully prepared. Different conditions gave different shapes of drug-polymer micro particles in the SEM results. Finally, dissolution rate of the drug-polymer micro particles in the simulated gastric fluid showed promising results.

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