Date of Award

8-2014

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Environmental Science

First Advisor

Dr. Khaled Amiri

Second Advisor

Dr. Sofyan Alyan

Third Advisor

Dr. Mohsin Sulaiman Alaamri

Abstract

Human Y chromosome is a specific male marker and it consists of the largest non-recombining segment in human genome that is the hallmark of Y chromosome population-based studies.This stud establishes an extensive Y poly-morph ism profile of the U A E Population and to our knowledge, this is the largest study carried out in the UAE.

DNA samples were for 1 7 polymorphic STR from 345 unrelated Emirate male. In UAE population, the analysis of the allele frequency clearly shows that each u ha a predominant allele. It is also apparent that alleles for most loci are clustered over a narrow range \ here approximately 60% - 80% of the population is sharing a specific allele for the locus. Moreover, the highest diversity were observed at locus DYS458 = 0.9, DYS3 85-A = 0.9 and DY 3 85 -B = 0.9. Therefore, they should be considered as the most Variable and most informative markers for forensic testing. While, loci with the Lover diversity are the least informative loci ( i .e. DYS392 which equal 0.437).

The UAE population is largely heterogeneous and a total of 3 0 1 different Haplotype were identified. There are 271 unique haplotype and 22 haplotype were Shared between 1:\\ 0 individuals. There are three cases \ here four. Five and six Individuals are sharing identical haplotype. Moreover, there are three different Haplotype shared by five individuals. This is likely due to the sharing of mo t Common recent ancestors. This brings the discrimination capacity to approximately 90% and haplotype diversity 99.885%. This is fundamental to understanding the Degree of heterogeneity in E population and can reflect the pattern of the Migration, geographic influence, and cultural influence. Secondly. The study provide An array of haplotype that can serve as database for forensic uses . To this end. United Arab Emirate population is divers and are genetically close to neighboring Countries. Analysis of molecular variance (M VA) how no significant genetic Differences within U A E population or population residing the Arabian Gulf region.

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